IgE: Immunoglobulin E; TSLP: Thymic stromal lymphopoietin.
TSLP is a key epithelial cytokine
that sits at the top of the inflammatory cascade and offers a new way to think about severe asthma.1-3
There is compelling evidence that TSLP plays a major role in the pathology of asthma.4
Watch the Mechanism of Disease Video
to learn more about the role of TSLP in severe asthma.
References: 1. Corren J. J Allergy Clin Immunol Pract. 2019;7(5):1394-1403. 2. Lambrecht BN, Hammad H, Fahy JV. Immunity. 2019;50(4):975-991. 3. Lambrecht BN, Hammad H. Nat Immunol. 2015;16(1):45-56. 4. Gavreau G, Sehmi R, et al. Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma. Expert Opin Ther Targets. 2020 Aug;24(8):777-792. 5. Liang Y, Yu B, Chen J, et al. J Allergy Clin Immunol. 2019;144(4):1025-1035. 6. Li Y, Wang W, Lv Z, et al. J Immunol. 2018;200(7):2253-2262. 7. Tanaka J, Watanabe N, Kido M, et al. Clin Exp Allergy. 2009;39:89-100.8. Chesné J, Braza F, Mahay G, et al. Am J Respir Crit Care Med. 2014;190(10):1094-1101. 9. Ying S, O'Connor B, Ratoff J, et al. J Immunol. 2005;174(12):8183-8190.